CIAO:一个跨学科大规模合作的活体实验,通过不良结果路径框架来促进
Annamaria Carusi1, Julija Filipovska2, Clemens Wittwehr3
1Interchange, London, United Kingdom.
Frontiers in public health
|August 28, 2023
概括
不良结果途径 (AOP) 框架成功支持跨学科合作和众包用于COVID-19研究. 它的结构化方法促进了知识的整合,并突出了在大型科学努力中适应的领域.
科学领域:
- 利用不利结果途径 (AOP) 知识管理框架进行跨学科科学合作和数据集成.
背景情况:
- 随着COVID-19的流行,大量的数据产生了差异,需要新的合成方法.
- 最初用于化学风险评估的不良结果途径 (AOP) 框架被探索其在整合不同类型数据方面的潜力.
研究的目的:
- 评估AOP框架在促进病毒性疾病的跨学科合作方面的有效性.
- 评估AOP框架作为众包合作模式的概念调解者的实用性.
主要方法:
- 一项调查分发给了CIAO项目参与者.
- 为CIAO贡献者举办了一场研讨会.
- 与选定的参与者进行了采访.
- 对项目流程进行了自我反思.
主要成果:
- AOP框架促进了真正的跨学科性和知识交流,作为一个共同的参考点.
- 在AOP-Wiki展示了新用户的可用性挑战,表明需要适应,特别是调节因素.
- 通过AOPs成功进行众包,需要强大的中央组织和早期明确协作条款.
结论:
- AOP框架有效地支持科学研究中的跨学科合作和众包.
- 为了更广泛的可用性,需要对AOP框架进行调整,例如对调制因子进行调整.
- 美国中央情报局 (CIAO) 项目的方法为将AOP应用于系统知识组织的其他科学领域提供了一个模型.
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