骨髓相关的分化标记与2型喘有关,并由人类犀牛病毒感染上调
Sasipa Tanyaratsrisakul1, Alane Blythe C Dy1, Francesca Polverino2
1Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, United States.
Frontiers in immunology
|August 28, 2023
概括
增加MYADM表达与喘严重程度和鼻病毒感染有关. 这种蛋白质对于炎症基因表达至关重要,可能会使喘和恶化情况恶化.
科学领域:
- 免疫学 免疫学 免疫学
- 呼吸系统医学 呼吸系统医学
- 分子生物学分子生物学
背景情况:
- 人类鼻病毒 (RV) 与儿童喘的发展和恶化有关.
- MYADM上皮表达与喘严重程度相关.
- 研究MYADM在喘和RV感染中的作用至关重要.
研究的目的:
- 为了确定MYADM表达是否在喘和/或鼻病毒感染中发生变化.
- 评估MYADM表达与喘相关因素之间的关联.
主要方法:
- 使用的H1HeLa细胞和人类呼吸道原发性上皮细胞 (AECs).
- 通过qRT-PCR测量了MYADM和炎症基因表达.
- 利用了MYADM的siRNA淘汰和一个卵素挑战的小鼠喘模型.
主要成果:
- 在RV-1B感染后,小鼠肺部和人类AEC中的MYADM表达增加.
- 在空气道上皮质细胞中,MYADM主要存在于地下囊泡膜上.
- 炎症基因表达需要MYADM的存在,即使在RV-1B或多I:C治疗后也是如此.
结论:
- 在喘模型和RV-1B感染期间观察到MYADM表达的增加.
- MYADM表达与炎症基因增加有关,可能会恶化喘.
- MYADM可能在VR相关的喘恶化中发挥作用.
更多相关视频
06:08Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
Published on: September 22, 2023
1.8K
08:42Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures
Published on: May 26, 2023
3.0K
相关概念视频
01:26Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
01:30Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K