光纳米和微粒用于感知细胞微环境:过去,现在和未来的应用
Giuliana Grasso1, Francesco Colella1,2, Stefania Forciniti1
1Institute of Nanotechnology, National Research Council (CNR-NANOTEC) c/o Campus Ecotekne, via Monteroni 73100 Lecce Italy giuliana.grasso@nanotec.cnr.it loretta.delmercato@nanotec.cnr.it.
Nanoscale advances
|August 28, 2023
概括
放射测量光探针提供了对瘤微环境 (TME) 的精确见解,检测了诸如酸性和缺氧等关键标志. 这些先进的传感器对于早期癌症检测,诊断和开发新的治疗策略至关重要.
科学领域:
- 生物医学工程 生物医学工程
- 化学传感器 化学传感器
- 癌症研究 癌症研究
背景情况:
- 瘤微环境 (TME) 呈现出独特的特征,如酸化,缺氧,反应性氧物种 (ROS) 生成和改变的离子流.
- 这些TME特征是早期癌症检测,诊断和治疗干预的关键目标.
- 目前的成像和传感技术用于可视化和监测研究和临床环境中的细胞和TME动态.
研究的目的:
- 审查TME光学映射的比例计光探针的最新进展.
- 阐明这些探测器的pH,氧,ROS,离子和生物标志物的结构设计,传感机制和应用.
- 探索综合传感平台和高分辨率成像技术,用于分析复杂的瘤培养物.
主要方法:
- 关于用于TME传感的比度光探针的综合文献综述.
- 对探头结构设计和传感机制的分析.
- 在体外和体内检测应用的评估,包括集成的传感平台和计算方法.
主要成果:
- 基于光的比度测量传感器为TME提供了精确而敏感的洞察力.
- 这些传感器可以实时检测和跟踪TME的动态变化.
- 进步包括探测器在TME内进行pH,氧,ROS,离子和生物标志物的光学映射.
结论:
- 电比测量光探头是了解TME动态的强大工具.
- 综合传感平台与先进的成像和计算方法相结合,为高分辨率分析提供了潜力.
- 光纳米和微粒子在癌症研究的细胞微环境传感中具有显著的未来潜力.
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