肉调节了阿姆洛迪平在高血压大鼠中的药理动力学和药理动力学
Ibrahim Abdelsalam Abdelrahman1, Abdul Ahad1, Mohammad Raish1
1Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
概括
肉增强了阿姆洛迪平的功效.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 自然产品研究自然产品研究
背景情况:
- 高血压是一种普遍的心血管疾病.
- 阿姆洛迪平是一种广泛使用的抗高血压药物.
- 像肉这样的天然产品因其潜在的健康益处而受到探索.
研究的目的:
- 为了研究 cinnamon 和 amlodipine 对高血压大鼠的联合作用.
- 评估肉对阿姆洛迪平的药理动力学 (PK) 和药理动力学 (PD) 的影响.
主要方法:
- 在使用L-NAME的Wistar大鼠中诱导高血压.
- 鼠被单独用L-NAME治疗,或用L-NAME加肉治疗.
- 监测血压,并使用UPLC-LCMS/MS分析amlodipine的PK概况.
主要成果:
- 在用阿姆洛迪平治疗的老鼠中,使用肉协同降低了血压.
- 肉显著增加了阿姆洛迪平的最大度 (Cmax) 和曲线下的面积 (AUC0-t).
- 杏的Cmax和AUC0-t分别为11.04 ± 1.01 ng/ml和113.76 ± 5.62 ng·h/ml,在肉的存在下.
结论:
- 在大鼠模型中,肉增强了阿姆洛迪平的抗高血压作用.
- 肉改善了阿姆洛迪平的药物动力学参数,这表明药物与草药相互作用的可能性.
- 需要进一步的研究来探索肉在高血压管理中的作用及其与心血管药物的相互作用.
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