在非酒精性脂肪肝疾病中的抑郁症和所有原因/特定原因死亡率
Donghee Kim1, Richie Manikat1, Anjiya Shaikh2
1Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.
European journal of clinical investigation
|August 28, 2023
概括
非酒精性脂肪肝 (NAFLD) 患者的抑郁症增加了因所有原因和心血管疾病死亡的风险. 由于抑郁症导致的功能障碍进一步增加了这些死亡风险,突出了心理健康和肝脏疾病结果之间的关键联系.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 越来越多的人认识到非酒精性脂肪性肝病 (NAFLD).
- 抑郁症和NAFLD结果之间的关联,特别是死亡率,需要进一步调查.
- 了解这种联系对于全面的患者护理至关重要.
研究的目的:
- 调查抑郁症和全因/特定原因死亡率在美国成年人中与NAFLD之间的关联.
- 检查抑郁症导致的功能障碍对NAFLD患者死亡风险的影响.
主要方法:
- 来自2007-2016年国家健康和营养检查调查的11877名NAFLD患者的分析.
- 基于肝肥胖症指数的NAFLD诊断,不包括其他慢性肝病.
- 使用患者健康问卷评估抑郁症和功能障碍,与到2019年的死亡率数据联系在一起.
主要成果:
- 患有NAFLD和抑郁症的个体的全因死亡率高出35% (HR:1.35).
- 由于抑郁症导致功能障碍的NAFLD患者的全因死亡率高出62% (HR: 1.62).
- 抑郁症与心血管死亡率增加50%有关,功能障碍患者的风险增加2倍 (HR:2.07). 没有观察到癌症或意外死亡率的显著差异.
结论:
- 抑郁症是NAFLD患者全因和心血管死亡率增加的重要危险因素.
- 与抑郁症相关的功能障碍加剧了NAFLD的死亡风险.
- 这些发现强调了在NAFLD管理中解决抑郁症的重要性.
相关概念视频
Ultrasound II: Endoscopic Ultrasound and FibroScan
137
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
137
Diseases of the Liver and Gallbladder
622
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
622
Depressive Disorders: MDD and Dysthymia
175
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
175
Depressive Disorders: Etiology
137
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
137
Long-term Depression
2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.6K
Depression: Overview
274
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
274


