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[抗氧化剂治疗对原发性开角绿内障的一些病原遗传因素的影响]

T N Malishevskaya¹, Yu E Filippova²

¹Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia.

Vestnik oftalmologii

|August 28, 2023

概括

麦克西多尔在患有初级开角绿内障 (POAG) 的患者中显示出显著的益处. 该药物改善了内皮功能,减少了氧化应激,并减缓了动脉动脉生成,为玻璃眼患者提供了保护作用.

科学领域:

眼科医生眼科眼科
心血管研究研究心血管研究
药理学药理学是指药理学的学科.

背景情况:

内皮功能障碍 (ED) 扰乱了血管调节的调节,这是绿眼病进展的关键因素.
介导体中ED失衡有助于形态损伤,失脂血症和动脉动脉产生.
墨西多尔表现出广泛的药理活性,影响了初级开角青光眼 (POAG) 的关键病原遗传机制.

研究的目的:

分析Mexidol在POAG患者的血管改造效应.
评估POAG中Mexidol的抗氧化和抗毒性质.
评估Mexidol对内皮功能和动脉生成标记物的影响.

主要方法:

研究包括78名POAG患者 (早期和晚期).
墨西多尔与低血压治疗同时给主要组 (n=47);对照组 (n=31).
通过反应性高血压评估内皮功能,测量血内皮素-1和亚酸盐水平,评估氧化应激,并进行电网膜学和计算机周边测量.

主要成果:

麦克西多尔改善了振荡潜力,降低了峰值延迟,并显示了周边度指数的积极趋势.
观察到增强的内皮功能,降低ET-1,增加酸盐,降低血管活动.
麦克西多尔增加了谷氨过氧化酶,降低了甲,并改善了脂质代谢,降低了胆固醇和乙醇原性指数.

结论:

墨西多尔在POAG中起到有效的内皮保护作用.
这种药物表现出强大的抗氧化和抗毒性作用.
墨西多尔有助于减缓POAG患者的动脉动脉生成.

关键词:

墨西哥的墨西哥偶像.内皮质功能障碍内皮质功能障碍主要的开放角光眼 (Glaucoma)

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