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1型和2型糖尿病患者心肌功能指数的预后值:千&1和千&2研究
Hashmat Sayed Zohori Bahrami1,2, Peter Godsk Jørgensen2,3, Jens Dahlgaard Hove1,4
1Department of Cardiology, Copenhagen University Hospital, Amager & Hvidovre, Kettegård Alle 30, 2650 Hvidovre, Denmark.
European heart journal. Cardiovascular Imaging
|August 28, 2023
概括
心肌性能指数 (MPI) 预测了1型糖尿病 (T1D) 中的主要不良心血管事件 (MACE) 和心力衰竭,但不是2型糖尿病 (T2D). 心声学评估改善了T1D中心血管风险预测.
科学领域:
- 心脏病学 心脏病学
- 糖尿病学 糖尿病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 心血管疾病 (CVD) 是1型 (T1D) 和2型糖尿病 (T2D) 中的主要死亡原因.
- 目前的糖尿病风险预测模型缺乏心肌功能参数.
- 心肌性能指数 (MPI) 反映了左心室功能,但其在大量糖尿病人群中的预后价值尚未评估.
研究的目的:
- 在T1D和T2D的大队伍中评估MPI的预后值.
- 评估MPI是否可以改善糖尿病心血管风险预测.
主要方法:
- 两项前性队列研究 (Thousand&1用于T1D,Thousand&2用于T2D),分别涉及1093名和1030名患者.
- 收集了基线临床和心声学数据,并从国家登记处进行了跟进.
- 主要不良心血管事件 (MACE) 被定义为急性冠状动脉综合征,心力衰竭,中风或全因死亡率.
主要成果:
- 在调整后,MPI与T1D中的MACE (HR 1.2) 和心力衰竭 (HR 1.3) 独立相关.
- 在T2D中,MPI与MACE或心力衰竭没有显著的关联.
- 在添加到Steno T1风险引擎 (AUC增加) 时,MPI改善了T1D中MACE和心力衰竭的预测.
结论:
- MPI是T1D中MACE和心力衰竭的独立预测因素,但不是T2D.
- 对MPI的心声学评估提高了心血管风险预测,特别是在T1D中.
- MPI可能是T1D患者风险分层的一个有价值的工具.
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