在骨髓瘤局部控制之前的进展:结果和预后-预测因素
Hadeel Halalsheh1,2, Shrouq Amer1, Iyad Sultan1,2
1Department of Pediatric, King Hussein Cancer Center, Amman, Jordan.
Pediatric blood & cancer
|August 28, 2023
概括
在局部控制之前,骨髓瘤的早期疾病进展表明预后不佳. 局部疾病进展的患者表现得更好,因此需要对早期疾病进展的ifosfamide/etoposide (IE) 治疗进行进一步研究.
科学领域:
- 儿科瘤学 儿科瘤学
- 骨系统新生体
- 癌症的进展 癌症的进展
背景情况:
- 在局部控制 (LC) 之前早期骨髓瘤进展的预后和影响尚未得到充分研究.
- 在这种情况下,ifosfamide/etoposide (IE) 的潜在治疗益处需要进一步研究.
研究的目的:
- 调查儿科骨髓瘤患者的预后,这些患者在当地控制之前有早期疾病进展.
- 评估ifosfamide/etoposide (IE) 治疗对早期骨髓瘤进展的患者结局的影响.
主要方法:
- 在2006年6月至2022年3月期间诊断的儿科骨髓瘤患者 (≤18岁) 的回顾性研究.
- 分析的重点在于在局部控制 (LC) 之前经历疾病进展的患者.
主要成果:
- 在195名患者中,31名患者在LC前呈现进展;25名患者仅呈现局部进展,6名患者呈现局部/转移性进展.
- 与联合进展患者相比,只有局部进展的患者的结果更好.
- 五名患者接受了IE强化,所有患者的病情进展;无事件的5年生存率为27.2%,总生存率为31.3%.
结论:
- 在LC之前的早期骨髓瘤进展与预后不佳有关.
- 局部疾病进展可能有更好的结果,这表明有针对性的干预措施的潜力.
- 需要对更大的队列进行进一步的研究,以澄清IE在管理早期骨髓瘤进展中的作用.
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