在患有2型糖尿病的老年人中,在上坡增量循环运动期间肌肉脱氧
Adam McDermott1, Aaron Nevin1, Norita Gildea1
1Department of Physiology, School of Medicine, Trinity College Dublin, The University of Dublin, Dublin 2, Ireland.
European journal of applied physiology
|August 28, 2023
概括
与健康个体相比,患有2型糖尿病 (T2D) 的老年人在运动期间肌肉氧气提取增加. 这表明受损的微血管氧气输送有助于减少T2D的峰值氧气吸收.
科学领域:
- 运动生理学 运动生理学
- 代谢健康 代谢健康
- 衰老研究研究 衰老研究
背景情况:
- 2型糖尿病 (T2D) 与心血管并发症和运动能力降低有关.
- 了解肌肉氧气动力学对于评估T2D老年人群的运动限制至关重要.
研究的目的:
- 在增量循环期间调查T2D的老年人中分数氧气提取配置文件.
- 为了比较T2D患者和健康对照者之间的肌肉脱氧化模式.
主要方法:
- 近红外光谱学 (NIRS) 用于测量横向巨大的肌肉脱氧 (Δ[HHb+Mb]) .
- 参与者 (12名T2D,12名对照者) 进行了机场增量循环测试.
- 肌肉脱氧数据被规范化并使用双线性回归模型对输出功率 (PO) 进行分析.
主要成果:
- 患有T2D的个体的峰值氧气摄入量 (V·O2峰值) 显著低于对照组.
- 肌肉脱氧与绝对PO的斜率在T2D组中更.
- 脱氧的第二个线性阶段的开始发生在T2D组的运动强度较低时.
结论:
- 患有T2D的老年人对于给定的绝对输出功率表现出增强的微分氧提取.
- 微血管氧气输送受损可能导致该人群的V·O2峰值降低.
- 在运动期间,NIRS可以在T2D中揭示不同的肌肉氧气利用模式.
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