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在双极和单极抑郁症中,后扣带皮质和补充运动皮质之间的运动性能和功能连接

Lara E Marten¹, Aditya Singh¹, Anna M Muellen²

¹Laboratory of Systems Neuroscience and Imaging in Psychiatry (SNIP-Lab), Department of Psychiatry and Psychotherapy, University Medical Center Göttingen (UMG), Von-Siebold-Straße 5, 37075, Göttingen, Germany.

European archives of psychiatry and clinical neuroscience

|August 28, 2023

概括

双极性抑郁症中的精神运动缺陷与大脑连接的改变有关. 具体来说,受损的手指敲击性能与后带带皮层 (PCC) 和补充运动区域 (SMA) 之间的功能合减少相关.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
脑部成像脑部成像

背景情况:

精神运动缺陷在双极性 (BD) 和单极性 (UD) 抑郁症中很常见,但它们的神经生物学基础尚不清楚.
这些缺陷可能会影响抑郁症患者的治疗结果和日常功能.

研究的目的:

在BD和UD患者中,研究运动性能缺陷与原发动皮质 (M1),后带皮质 (PCC) 和补充运动区域 (SMA) 的休息状态功能连接之间的关系.
探索抑郁症中精神运动缺陷的神经生物学基础.

主要方法:

一项纵向,自然主义的研究涉及两次休息状态功能性MRI (fMRI) 会议,间隔五周.
使用手指敲击任务 (FTT) 评估BD,UD和健康对照 (HC) 个体的运动性能.
基于特定主体的种子分析,以检查PCC-SMA和M1-SMA之间的功能连接,使用线性回归模型来评估与运动性能之间的关系.

主要成果:

与HC相比,BD患者在FTT上的运动性能在两个会议中都显著受损.
所有组的行为表现与PCC-SMA的静止状态功能合有显著的相关性,但不是M1-SMA.
在第二次会议中,与HC相比,在BD患者中观察到PCC-SMA连接的减少,部分反映了行为发现.

结论:

双极性抑郁症中SMA和PCC之间的抗相关性中断与运动障碍的严重程度有关.
休息状态功能连接,特别是PCC-SMA合,为抑郁症中精神运动缺陷提供了潜在的神经生物学标志物.
需要进一步的研究才能充分阐明大脑网络与情绪障碍中的运动缺陷之间的复杂相互作用.

关键词:

双极性障碍是一种双极性障碍.手指敲打着自己的手指.大型抑郁症主要是抑郁症.后侧环状皮层的皮层.休息状态功能磁共振成像静止状态功能磁共振成像额外的发动机区域

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