基于SEER数据库的不同年龄段的结肠癌患者的生存名录的构建
Yuzhou Yang1,2, Peng Xu3, Cheng Zhang4,5
1Department of General Surgery, General Hospital of Northern Theater Command (General Hospital of Shenyang Military Command), Shenyang, Liaoning Province, China.
Journal of cancer research and clinical oncology
|August 28, 2023
概括
开发出来的诺姆图准确地预测结肠癌的结果. 这些工具,包括针对早期和晚期发病的特定工具,优于传统的TNM分期系统,用于个性化治疗.
科学领域:
- 在瘤学瘤学.
- 生物统计学 生物统计学
- 癌症预后 癌症预后
背景情况:
- 结肠癌预测结果缺乏特定年龄分层.
- 现有的预后模型需要提高临床效用.
研究的目的:
- 开发和验证结肠癌 (COCA) 预测结果的预测性名录.
- 为了比较这些名ograms与TNM分期系统的准确性.
主要方法:
- 使用了SEER数据库 (1975-2019) 包含6107名COCA患者.
- 用COX回归和生存分析来构建和验证名录.
- 使用校准曲线,ROC曲线和C指数评估预测准确度.
主要成果:
- 瘤部位,种族和CEA水平是显著的预后因素.
- 与TNM分期相比,名图显示出更高的准确性和区分能力.
- 早期发病的COCA nomogram表现出最高的预测准确性.
结论:
- 为COCA预后开发了三种准确的名图 (年龄分层和分层不分层).
- 在TNM系统中,Nomograms为个性化的COCA患者管理提供了更好的临床实用性.
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