一种低调的并发症:无家可归对创伤性脑损伤的影响
M Monsour1, J-Y Lee2, C V Borlongan3
1University of South Florida Morsani College of Medicine, 560 Channelside Dr., Tampa, FL, 33606, USA.
概括
无家可归加剧了创伤性脑损伤 (TBI) 的功能缺陷. 这项研究模拟了老鼠的TBI和无家可归 (HL),发现HL恶化了TBI相关的运动和白质损伤,突出了TBI结果中的环境因素.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 退伍军人事务 退伍军人事务
背景情况:
- 创伤性脑损伤 (TBI) 在无家可归人群中很普遍,但往往诊断不足和治疗不足.
- 由于共同的风险因素和潜在的生物相互作用,无家可归 (HL) 可能会显著恶化TBI结果.
研究的目的:
- 通过一种新的动物模型,研究无家可归对TBI引起的功能缺陷和白质完整性的影响.
- 阐明环境条件在TBI病理生理学和恢复中的作用.
主要方法:
- 成年斯普拉格-道利大鼠被分配到仅TBI,仅HL,TBI+HL或对照组.
- 无家可归是通过脏的床铺暴露在5周内模拟的,随后是中度控制的皮质冲击TBI.
- 进行了行为测试 (光束行走,升高的身体摆动,前肢健行症,手掌握,Rotorod) 和Nissl染色以检测细胞存活率和体完整性.
主要成果:
- 在所有测试行为中,TBI显著损害了运动功能.
- 无家可归加剧了TBI相关的缺陷,比如梁行走,前肢动和手掌握.
- 与单独的TBI相比,TBI+HL老鼠在白质完整性,特别是体内的白质完整性表现出显著的变化.
结论:
- 无家可归严重导致TBI后的功能缺陷和白质损伤.
- 无家可归等环境条件在TBI结果中起着至关重要的作用,这表明需要综合诊断和治疗方法.
- 这些发现强调了在治疗TBI时考虑患者的环境的重要性.
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