一种概率的方法来预测血糖在1型糖尿病下餐不确定性
IEEE journal of biomedical and health informatics
|August 28, 2023
概括
这项研究引入了一种新的深度学习模型,用于预测1型糖尿病患者的葡萄糖水平. 输入和状态循环卡尔曼网络 (ISRKN) 通过计算食不确定性来提高人工胰腺系统的准确性.
科学领域:
- 生物医学工程 生物医学工程
- 人工智能在医学中的应用
- 内分泌学 在内分泌学.
背景情况:
- 针对1型糖尿病的混合闭环人工胰腺系统需要手动预告餐点,容易出现错误.
- 不准确的饮食估计引入了不确定性,导致人工胰腺系统的葡萄糖控制不足.
- 解决这些不确定性对于提高自动化糖尿病管理的有效性至关重要.
研究的目的:
- 开发一种新的深度学习模型用于概率性葡萄糖预测,该模型明确估计了食不确定性.
- 通过结合强大的不确定性量化来提高人工胰腺系统的准确性和可靠性.
- 为了提高1型糖尿病管理中的葡萄糖控制结果.
主要方法:
- 提出了一个新的深度学习模型:输入和状态循环卡尔曼网络 (ISRKN).
- 在深度神经网络的潜伏空间内集成了输入和状态卡尔曼波器.
- 通过卡尔曼方程启用了后面分布和不确定性传播的闭式计算.
- 在过器内明确估计的食不确定性分布参数.
主要成果:
- 与其他概率模型相比,ISRKN模型表现出卓越的性能.
- 使用UVA/Padova模拟器和临床试验数据进行评估.
- 在不同程度的分布变化中展示了改进的概率指标.
结论:
- ISRKN模型有效地解决了人工胰腺系统的食估计中的不确定性.
- 使用ISRKN进行概率性葡萄糖预测,可以实现更准确,更可靠的葡萄糖控制.
- 这种方法在推进自动化糖尿病管理技术方面具有重大潜力.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.5K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.5K
Diabetes Mellitus: Overview and Type I Subtype
2.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.8K
Insulin: Dosing Regimen and Adverse Effects
205
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
205
Diabetes: Symptoms, Diagnosis, and Complications
588
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
588
Diabetes: Management and Pharmacotherapy
310
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
310
Carbohydrate Metabolism
11.2K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.2K


