在DENV感染的抗体依赖增强过程中,DENV特异性IgA有助于保护性和非病理性功能
Adam D Wegman1, Mitchell J Waldran1, Lauren E Bahr1
1Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, New York, United States of America.
PLoS pathogens
|August 28, 2023
概括
免疫球蛋白A (IgA) 通过防止抗体依赖增强 (ADE) 在登革热感染中发挥保护作用. 与IgG不同,IgA不会增强登革热病毒感染或促炎反应,这表明其具有治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 登革热病毒 (DENV) 感染对全球健康构成重大威胁,先前感染增加了严重疾病的风险.
- 通过IgG抗体对抗体依赖增强 (ADE) 是严重登革热发病的关键因素.
- 之前的研究表明,DENV反应性IgA可以中和DENV,并对抗IgG介导的ADE.
研究的目的:
- 调查IgA的潜力,以调解登革热病毒感染的ADE.
- 为了比较IgA和IgG对DENV感染和免疫反应的影响.
- 在登革热感染期间分析Fc受体的表达.
主要方法:
- 在体外实验中使用表达FcαR和FcγR的细胞来评估IgA和IgG的ADE.
- 测量人类原发性巨细胞对促炎性细胞因子的产生.
- 对DENV免疫复合体与敏感细胞结合的分析.
- 流细胞计测量以确定登革热感染期间的Fc受体表达.
主要成果:
- IgG,但不是IgA,是DENV感染的介导ADE.
- 通过IgG介导的ADE诱导了比单独的IgA或病毒更高的促炎细胞因子产生.
- DENV/IgG免疫复合体比DENV/IgA复合体更有效地结合细胞.
- 在急性病毒病期间,FcγR表达增加,而FcαR表达减少.
结论:
- 在登革热感染中,IgA表现出对ADE的保护作用.
- 与IgG不同,IgA不会导致感染或炎症的增强.
- 特定于DENV的IgA对登革热病具有潜在的治疗和预后价值.
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