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在痴呆症中治疗神经精神病症状的管理
1Professor of Psychiatry and Neurology, Director Brain Aging and Mental Health, Department of Psychiatry, New York State Psychiatric Institute and Columbia University Irving Medical Center, USA.
Current opinion in neurology
|August 28, 2023
概括
阿尔茨海默病和相关痴呆症中的神经病理与神经精神症状 (NPS) 有关. 像布雷克斯皮普拉 (brexpiprazole) 这样的新疗法在治疗痴呆症患者的兴奋和冷漠方面表现有前途.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 神经精神症状 (NPS) 在阿尔茨海默氏症 (AD) 和相关痴呆症中很常见.
- 了解神经病理和NPS之间的联系对于有效治疗至关重要.
研究的目的:
- 审查最近关于神经病理学和痴呆症中NPS的研究.
- 讨论与痴呆相关的NPS的临床影响和新兴治疗策略.
主要方法:
- 对尸检研究的综述,这些研究将神经病理与NPS严重程度相关联.
- 对新的痴呆症治疗方法的临床试验数据的分析.
主要成果:
- 增加NPS的严重程度与痴呆症亚型中较大的神经病理相关.
- 布雷克西普拉被批准用于阿尔茨海默氏症痴呆症的激发,显示出适度的疗效和高安全性.
- 目前正在进行的对大麻素,甲基增强剂和甲基酸对冷漠的试验.
结论:
- 更好地了解NPS与痴呆症的联系可以提高临床管理.
- 新的治疗方案提供了希望,但长期预后影响仍然是一个挑战.
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