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AMPK-FOXO-IP3R信号通路介导由线粒体DNA突变引起的神经和发育缺陷

Hu Zhang1, Yunan Zhu1, Yuji Suehiro2

  • 1Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309.

Proceedings of the National Academy of Sciences of the United States of America
|August 28, 2023
PubMed
概括

线粒体DNA (mtDNA) 突变通过破坏细胞能量和信号传递,导致神经和发育问题. 维生素MK-4治疗可以恢复细胞功能并改善模型生物的结果.

关键词:
由AMP激活的蛋白质激酶激活的蛋白质激酶.凯诺哈比迪斯的优雅的植物.的恒常性是的恒常性.线粒体基因组突变的突变神经和发育缺陷的神经和发育缺陷

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