对于IVM来说,这是一个新的开始:使用IVM前的方法使卵细胞能够发育
Robert B Gilchrist1, Tuong M Ho2, Michel De Vos3,4
1Fertility & Research Centre, Discipline of Women's Health, School of Clinical Medicine, University of New South Wales Sydney, NSW, Australia.
Human reproduction update
|August 28, 2023
概括
在体外成熟 (IVM) 的最新进展包括双相方法,利用未成熟卵细胞的IVM前培养. 这种新的技术有望改善ART的结果,特别是在PCOS患者中.
科学领域:
- 生殖生物学和辅助生殖技术 (ART).
- 卵细胞生物学,成熟和发育能力.
- 毛囊发育和卵巢刺激协议.
背景情况:
- 卵细胞的体外成熟 (IVM) 尚未在全球范围内获得广泛的临床采用.
- 动物卵细胞生物学最近的突破刺激了新的IVM方法.
- 双相IVM,涉及IVM前的步骤,是最近取得的重大进展.
结论:
- 双相IVM,以CAPA-IVM为例,提供了一个低干预,患者友好的ART替代方案.
- 使用CAPA-IVM的临床结果表明,与传统试管婴儿相比,活产率相当.
- 这种方法对PCOS患者,生育能力的保护和社会卵细胞冷具有潜力.
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