在肝脏疾病中的侵入性真菌感染
Nicolas Barros1,2, Russell E Rosenblatt3, Meaghan M Phipps4
1Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Hepatology communications
|August 28, 2023
概括
患有肝病的患者面临侵入性真菌感染 (IFI) 的高风险. 本综述更新了关于IFI流行病学,病因发生,诊断和管理这些脆弱患者的知识.
科学领域:
- 肝病学和传染病的研究
- 菌类学 菌类学是指菌类学.
背景情况:
- 患有肝病的患者,包括肝硬化和肝炎,极易患入侵性真菌感染 (IFI).
- 这些感染对该人口的发病率和死亡率作出了重大贡献.
- 危险因素包括免疫功能障碍,营养不良和微生物组变化.
研究的目的:
- 为肝病患者提供侵入性真菌感染 (IFI) 的最新概述.
- 涵盖流行病学,病原性,诊断方法和管理策略.
主要方法:
- 关于IFI在肝病患者中的当前文献的综述.
- 综合有关诊断方法和治疗的信息.
主要成果:
- 坎迪达菌种是最常见的IFI病因,但阿斯伯吉勒斯菌,密码球菌,肺囊菌和特有真菌也越来越被认可.
- 诊断依赖于病原体检测 (培养,组织病理学) 或分子/血清学标记 (抗原,抗体,核酸).
结论:
- 侵入性真菌感染对肝病患者和肝移植接受者构成重大威胁.
- 早期诊断和适当的管理对于改善结果至关重要.
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