与男性循环性激素相关的因素:个人参与者数据的元分析
Ross J Marriott1, Kevin Murray1, Robert J Adams2
1School of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia (R.J.M., K.M.).
Annals of internal medicine
|August 28, 2023
概括
男性的水平在70岁以后下降,肥胖,糖尿病或癌症患者的水平更低. 年龄,BMI和健康状况等因素显著影响男性激素度.
科学领域:
- 内分泌学 在内分泌学.
- 男人的健康 男人的健康
- 生殖健康 生殖健康
背景情况:
- 男性的循环丸激素水平受到各种因素的影响,使测量结果的解释变得复杂.
- 了解这些调节因素对于准确的临床评估至关重要.
研究的目的:
- 确定和澄清与男性性激素度的变化相关的社会人口统计学,生活方式和健康相关因素.
- 提供对影响总,SHBG和LH水平的因素的全面分析.
主要方法:
- 系统的文献搜索一直持续到2019年7月.
- 分析了9项前性队列研究 (n=21,074) 的个人参与者数据和2项研究 (n=4,075) 的综合数据.
- 在两个阶段的随机效应元分析中,针对与激素度相关的社会人口统计学,生活方式和健康因素进行了分析.
主要成果:
- 丸激素与年龄有非线性关联,水平稳定到70岁,然后下降.
- 较高的体重指数 (BMI),婚姻,减少剧烈的体力活动,以前的吸烟,高血压,心血管疾病,癌症和糖尿病都与较低的丸激素度有关.
- 性激素结合型全球蛋白 (SHBG) 与年龄直接相关,与BMI反向相关,而黄素化激素 (LH) 在70岁以上的男性中随年龄增加.
结论:
- 多种因素,包括年龄 (尤其是>70岁),肥胖,糖尿病和癌症,与男性丸激素,SHBG和LH度的变化有显著联系.
- 降低丸激素和70后增加的LH可能表明丸功能受损.
- 准确解释测量需要考虑这些关键影响因素.
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