全身麻醉改变了老鼠肺部微生物群的多样性和组成
Rui-Zhi Yang1, Min Liang1, Song Lin1
1Department of Anesthesiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China; Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|August 28, 2023
概括
使用异氨酸的吸入麻醉显著改变了老鼠的肺微生物组,增加了Elusimicrobia,导致类似抑郁症的行为. 普罗波对肺微生物群的影响较小.
科学领域:
- 微生物学 微生物学
- 麻醉学 麻醉学
- 神经科学是一个神经科学.
背景情况:
- 肺部微生物群对健康至关重要,影响免疫力和行为.
- 肺微生物组的破坏与各种健康问题有关.
- 一般麻醉剂对肺微生物组的影响尚未完全理解.
研究的目的:
- 为了研究一般麻醉剂 (propofol和isoflurane) 对大鼠肺部微生物组的影响.
- 探索麻醉引起的肺微生物组变化和神经行为结果之间的关系.
主要方法:
- 雄性SD大鼠接受了静脉注射的普罗波福尔或吸入的异黄素4小时.
- 16S rRNA 基因测序的支气管洗液 (BALF) 分析了肺部微生物组合.
- 神经行为测试 (EPM,OFT) 评估了麻醉后的行为.
主要成果:
- 异氨酸显著改变了肺微生物群的多样性和丰富性,超过了propofol.
- 在异黄素组中观察到Elusimicrobia的显著增加.
- 异氨酸麻醉在老鼠中诱导了类似于抑郁的行为,并与此相关的微生物组路径变化.
结论:
- 吸入的异氨酸会改变大鼠肺部微生物群的多样性和组成.
- 这些变化与麻醉后类似抑郁症行为的发展有关.
- 这项研究强调了麻醉剂,肺微生物组变化和神经效应之间的联系.
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