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Updated: Jul 17, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Published on: September 20, 2018

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H3K4me3重塑诱导通过O-GlcNAc转移酶获得的耐药性

Dinoop Ravindran Menon1, Heinz Hammerlindl2, Gregory Gimenez3

  • 1Frazer Institute, The University of Queensland, Brisbane, QLD, Australia; Department of Dermatology, University of Colorado Denver, Aurora, CO, USA; Department of Medical Oncology, University of Colorado Denver, Aurora, CO, USA.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
|August 28, 2023
PubMed
概括

通过O相关的N-乙糖胺转移酶 (OGT) 改造的素H3 lysine-4三甲基化 (H3K4me3) 驱动癌症的适应性耐药性. 抑制OGT或其上游激活剂AMPK延迟了获得的抵抗,提供了新的治疗策略.

关键词:
获得的耐药性 获得的耐药性适应性癌症药物耐药性 适应性癌症药物耐药性癌症持续存在的情况.细胞重新编程的细胞重编程.表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.H3K4me3是什么意思 H3K4me3是什么意思代谢过程中的代谢.其他 OGT 产品.在TET1上.

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