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在肺癌患者中,COVID-19疫苗的免疫性

Mariano Provencio¹, Anna Estival², Fernando Franco¹

¹Medical Oncology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.

Lung cancer (Amsterdam, Netherlands)

|August 28, 2023

概括

肺癌患者对COVID-19疫苗产生了强大的免疫反应,无论癌症治疗如何,都证明了安全性和有效性. 这项研究强调了疫苗在这个脆弱人群中的有效性.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
传染性疾病传染性疾病

背景情况:

患有肺癌的患者面临SARS-CoV-2感染和严重的COVID-19结果的风险增加.
关于抗SARS-CoV-2疫苗在肺癌患者中有效性的数据有限.

研究的目的:

在肺癌患者中评估COVID-19疫苗的安全性和免疫性.
在这个队列中确定与疫苗接种后血清阴性相关的因素.

主要方法:

一个前性的,全国性的SOLID副研究,涉及完全接种疫苗的肺癌成年人.
疫苗接种后两周和六个月血清抗SARS-CoV-2 IgG抗体水平的定量评估.
多变量逻辑回归用于分析临床因素和血清消极性之间的关联.

主要成果:

1973名肺癌患者被录取;大多数患者患有第四阶段疾病,正在接受癌症治疗.
在第二剂疫苗接种后两周观察到高抗体标位 (93.6%).
免疫疗法,口服向治疗和mRNA-1273疫苗与更高的血清阳性率有关. 糟糕的表现状态 (≥2) 在六个月后增加了血清负性的几率.

结论:

肺癌患者在接受完整的COVID-19疫苗接种后可以获得强大而安全的免疫反应.
疫苗的有效性保持不论正在进行的癌症治疗.
特定的疗法和疫苗类型会影响免疫反应水平.

关键词:

在 COVID-19 疫情中,免疫反应的免疫反应.肺癌是一种肺癌.中和抗体的抗体.这就是SARS-CoV-2病毒.疫苗疫苗疫苗疫苗

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