分子印制复合膜具有交联印制网络结构,用于高度选择性地分离actoside
Yingying Fan1, Chen Chen1, Xiaobin Zhao1
1School of Chemistry and Chemical Engineering/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering, Shihezi University, Shihezi 832003, China.
Journal of chromatography. A
|August 28, 2023
概括
这项研究开发了新型分子印制复合膜,用于选择性actoside (ACT) 分离. 新的膜显示出从自然来源提取有价值的ACT的高容量和选择性.
科学领域:
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
- 生物技术是生物技术.
背景情况:
- 乙酸 (ACT) 是一种在Cistanche tubulosa中发现的有价值的药用化合物,但其较低的自然丰度需要高效的提取方法.
- 开发选择性分离材料对于将ACT和其他生物活性成分从复杂的天然产品混合物中分离出来至关重要.
研究的目的:
- 设计和制造ACT分子印制复合膜 (A-MICMs),用于高度选择性的ACT分离.
- 为了优化A-MICMs的合成条件,并评估它们的吸附和分离性能.
主要方法:
- 通过在聚多巴胺修饰的聚乙烯化物 (pDA@PVDF) 中引入氨基多面寡合性六基 (NH2-POSS) 来制造NH2-POSS-pDA@PVDF膜.
- 在NH2-POSS-pDA@PVDF表面合成ACT打印的层,以创建A-MICM.
- 优化合成参数,包括多巴胺 (DA) 度,聚合时间,NH2-POSS量和洗时间.
主要成果:
- 确定了A-MICMs.的最佳合成条件.
- 吸附异温和动力学研究表明,由化学吸附驱动的单层吸附机制.
- A-MICM的最大重结能力为98.37mg·g-1,选择性为4.63和永久选择性为7.02.
- 膜在5个吸附-脱附周期后保持了95.99%的容量.
结论:
- 开发的A-MICM具有有效的交联印记网络结构,用于选择性ACT分离.
- 这些膜具有显著的潜力,可以有效地将生物活性成分从天然产品中分离出来.
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