阻塞性睡眠呼吸暂停的长度风险因素:系统性审查
Yaoyao Qian1, Shyamali C Dharmage1, Garun S Hamilton2
1Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie St, Carlton, Victoria, 3053, Australia.
Sleep medicine reviews
|August 28, 2023
概括
体重增加是发展阻塞性睡眠呼吸暂停 (OSA) 的重要危险因素. 即使体重增加10%,特别是在男性中,也可能表明潜在的或恶化的OSA,需要临床关注.
科学领域:
- 睡眠医学 睡眠医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 构成了相当大的健康负担.
- 目前存在的OSA风险因素证据主要来自横截面研究,缺乏时间性.
- 在一般成年人群中对OSA风险因素的纵向数据有限.
研究的目的:
- 系统地审查睡眠研究评估的OSA的纵向风险因素.
- 从队列研究中确定调查问卷评估的可能OSA的风险因素.
- 综合关于风险因素和OSA发展之间的时间关联的证据.
主要方法:
- 对Embase和Medline数据库进行系统的文献搜索.
- 在一般成年人群中包括11项队列研究.
- 由于方法异质性,进行了定性合成;并未进行元分析.
主要成果:
- 一致的证据将体重增加与OSA事件和严重程度的增加联系在一起.
- 发现较高的BMI,男性性别,喘,特定的遗传多态化 (rs12415421) 和胰岛素抵抗与发生的OSA相关联.
- 长期暴露于环境空气污染 (NO2) 和更年期过渡也与OSA或其严重程度有关.
结论:
- 体重增加约10%,特别是在男性中,可能表明潜在的或恶化的OSA.
- 需要进一步进行大规模,精心设计的纵向研究.
- 建议专注于可修改的OSA发展风险因素.
相关概念视频
Sleep Apnea
184
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
184
Other Pulmonary Disorders
870
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
870
Chronic Obstructive Pulmonary Disease
1.3K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.3K
Factors Affecting Pulmonary Ventilation
1.4K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.4K
Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
Insufficient Sleep and Sleep Deprivation
167
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
167


