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与酒精有关的肝病:肝病是否有安全的酒精消费限制?
Katrina Pekarska1, Richard Parker1
1Leeds Liver Unit, St James's University Hospital, Leeds, West Yorkshire, United Kingdom.
对于没有酒精相关肝病 (ALD) 的个人来说,低酒精摄入量带来最小的风险. 然而,一旦诊断出ALD,完全戒酒对于健康和生存至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 酒精消费是全球肝脏疾病的主要原因之一.
- 了解安全的酒精摄入水平对于预防与酒精有关的肝病 (ALD) 至关重要.
- 个别的风险因素显著影响疾病的发展.
研究的目的:
- 在ALD的背景下评估安全的酒精消费限值.
- 评估与不同程度的酒精摄入量相关的风险.
- 为了确定ALD出现后继续饮酒的影响.
主要方法:
- 对有关酒精消费和肝脏疾病的现有文献的综述.
- 分析酒精摄入量与ALD风险之间的剂量反应关系.
- 对已确诊的ALD患者的自然史研究的评估.
主要成果:
- 每天少于12-20克的酒精摄入量和无酒精日显示,易受感染的个体患ALD的风险非常低.
- 风险是由包括性别,并发症,肥胖和遗传学在内的辅因子调节的.
- 没有观察到零风险的明确值;存在剂量反应关系.
- 在患有ALD的患者中,持续饮酒显著增加了发病率和死亡率.
结论:
- 在缺乏疾病的情况下,低水平的酒精消费对发展ALD的风险很小.
- 对于被诊断患有ALD的人来说,强烈建议完全戒酒,以防止严重的健康后果和过早死亡.
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