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对斯洛文尼亚废水中抗抑郁药物的回顾性时空空间研究
Maria Laimou-Geraniou1, Maarten Quireyns2, Tim Boogaerts2
1Jožef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia; Jožef Stefan International Postgraduate School, Jamova 39, 1000 Ljubljana, Slovenia.
The Science of the total environment
|August 28, 2023
概括
废水流行病学显示,在COVID-19大流行期间,斯洛文尼亚的抗抑郁药消费量增加. 废水中的抗抑郁剂水平显示出显著的变化,大多数生物标志物在大流行的第一波期间上升.
科学领域:
- 环境化学环境化学
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 基于废水的流行病学 (WBE) 是监测人口水平药物消费的一个有价值的工具.
- 了解抗抑郁药使用的时间趋势对于公共卫生规划至关重要,尤其是在COVID-19大流行等危机期间.
研究的目的:
- 使用WBE. 评估斯洛文尼亚抗抑郁药消费的时空变化.
- 调查COVID-19大流行对抗抑郁药使用模式的影响.
主要方法:
- 从六个污水处理厂收集了210个24小时复合废水样本 (2019年夏季 - 2021年春季).
- 在固相提取后使用液体染色学-并联质谱分析了10种抗抑郁药物生物标志物.
- 计算人口规范化质量负载 (PNMLs) 来估计消耗.
主要成果:
- 乙甲基维拉法辛 (O-desmethylvenlafaxine),维拉法辛 (venlafaxine) 和西塔洛普拉姆 (citalopram) 是消费量最多的抗抑郁药.
- 平均代谢物/母化合物比率表明消耗,而不是直接处置.
- 大多数抗抑郁药生物标志物在第一波COVID-19浪潮 (2020年春季) 中显示PNMLs增加.
结论:
- 在斯洛文尼亚,WBE有效地监测了抗抑郁药物消费趋势.
- 在COVID-19流行病的初期阶段,抗抑郁药的消费量显著增加.
- 与大流行相关的消费没有明确的空间模式被确定.
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