控制用于释放药物的螺旋涂层多层乙基纤维素/基基纤维素薄膜的结构
Pierre Carmona1, Jens Poulsen2, Jan Westergren2
1Unit Product Design, Department Agriculture and Food, Division Bioeconomy and Health, RISE Research Institute of Sweden, Gothenburg, Sweden; Division Nano-and BioPhysics, Department of Physics, Chalmers University of Technology, Gothenburg, Sweden.
International journal of pharmaceutics
|August 28, 2023
概括
多孔的乙基纤维素/基基纤维素 (EC/HPC) 薄膜可以控制药物释放. 连续的旋转涂层揭示了由于层粗化和不混合而导致的梯度结构,影响透性.
科学领域:
- 材料科学 材料科学 材料科学
- 制药技术 制药技术 制药技术
- 化学工程是化学工程的重要组成部分.
背景情况:
- 多孔的乙基纤维素/基基纤维素 (EC/HPC) 薄膜对于控制药物从药物颗粒中运输至关重要.
- 工业颗粒涂层工艺产生不同孔径的分层薄膜,但形成机制尚不清楚.
研究的目的:
- 通过使用顺序旋转涂层来研究多层EC/HPC薄膜的形成和结构.
- 了解EC/HPC比率和旋转速度对薄膜特性的影响.
- 为了阐明相位分离和多层结构的起源.
主要方法:
- 通过EC/HPC薄膜的顺序旋转涂层模仿工业涂层.
- 先进的显微镜和图像分析用于结构特征.
- 卡恩-希利亚德模拟来分析聚合物混合行为.
主要成果:
- 形成了一个结构梯度,基板附近有较大的结构,空气表面附近有较小的结构,归因于层层粗化.
- 薄膜的多孔性因EC/HPC比率和旋转速度而有显著的变化.
- 模拟和现场表征证实了层不混合是不连续性和多层结构的原因.
结论:
- 序列沉积导致EC/HPC薄膜由于粗化而形成梯度结构.
- EC/HPC比率和旋转速度是控制薄膜孔隙性的关键参数.
- 层不混合是观察到的多层,分相结构背后的基本机制.
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