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Updated: Jul 17, 2025

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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粉样蛋白病理减少ELP3表达和tRNA修饰,导致蛋白质稳定性受损

Marisa Pereira1, Diana R Ribeiro1, Maximilian Berg2

  • 1Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.

Biochimica et biophysica acta. Molecular basis of disease
|August 28, 2023
PubMed
概括

阿尔茨海默病降低了ELP3,这是转移RNA (tRNA) 修饰的关键酶,损害了神经元蛋白质稳定. 恢复tRNA水平可能为阿尔茨海默病提供新的治疗策略.

关键词:
阿尔茨海默病的疾病阿尔茨海默病的疾病.延长器复合体子单位3 (ELP3)蛋白质稳定性 蛋白质稳定性翻译 翻译 翻译 翻译tRNA的修改 tRNA的改变

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