在患有稳定冠状动脉疾病的患者中,循环的曼诺斯结合性莱克度与心力衰竭和功能有关
Teng-Hung Yu1, Cheng-Ching Wu2, I-Ting Tsai3
1Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung 82445, Taiwan; School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan.
较高的曼诺结合性莱克 (MBL) 水平与稳定的冠状动脉疾病 (CAD) 患者的功能恶化和心力衰竭有关. 这表明MBL可能在慢性病和心力衰竭的发展中发挥作用.
科学领域:
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
背景情况:
- 曼诺结合性莱克 (MBL) 涉及到心血管疾病,糖尿病病和损伤.
- 在冠状动脉疾病 (CAD) 患者中,血MBL水平与心力衰竭或功能之间的特定关系尚不清楚.
研究的目的:
- 调查血MBL度与稳定CAD患者的功能和心力衰竭之间的关联.
主要方法:
- 纳入了348名稳定的CAD患者.
- 使用ELISA测量了血MBL度.
- 根据估计的膜过率 (eGFR) 将功能分类为KDIGO阶段.
- 心力衰竭被定义为左心室喷射率 (LVEF) ≤40%.
主要成果:
- 血MBL与糖尿病,吸烟,血液尿素,肌和大脑性尿素有积极的关联.
- MBL水平与eGFR和LVEF有负相关性.
- 较高的MBL三位数与晚期病 (KDIGO G3a-G4) 和心力衰竭的患病率增加相关.
- 多变量分析证实了MBL与晚期病和心力衰竭之间的独立关联.
结论:
- 在稳定的CAD患者中,循环的MBL度与功能受损和心力衰竭有关.
- 在这种人群中,血MBL增加可能会导致慢性病和心力衰竭的发病.
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