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频谱效应关系与生物活性评估相结合,发现了 Baihe Dihuang 开的主要抗焦虑活性成分

Lin Tang¹, Hong-Qing Zhao², Hui Yang¹

¹The First Hospital, Hunan University of Chinese Medicine, Changsha, Hunan Province, China.

Journal of ethnopharmacology

|August 28, 2023

概括

白河迪黄 (Baihe Dihuang) (BDD) 显示出显著的抗焦虑作用,其丁醇分数和14种特定化合物被确定为关键活性成分. 这项研究证实了这些化合物的有效性,改善了类似焦虑的行为和神经元健康.

科学领域:

药理学和中国传统医学 (TCM)
神经科学是一个神经科学.
分析化学分析化学

背景情况:

焦虑障碍显著损害生活质量,增加健康风险.
白河 (Baihe Dihuang decoction,简称BDD),是一种传统的中国配方,在治疗焦虑症方面有着悠久的历史.
负责BDD抗焦虑作用的特定药理活性成分仍未确定.

研究的目的:

为了确定 Baihe Dihuang (BDD) 中的主要抗焦虑成分.
为了确定BDD的化学成分和其抗焦虑活性之间的频谱效应关系.
通过实验验证已识别的活性成分.

主要方法:

超高性能液态染色学-四极飞行时间质谱学 (UPLC-Q-TOF/MS) 用于化学指纹和化合物识别.
使用行为测试 (开放场,高加迷宫) 和神经递质分析来评估抗焦虑效应.
通过相关性和回归分析确定了频谱效应关系,研究结果通过焦虑细胞模型在体外验证.

主要成果:

在BDD指纹中,UPLC-Q-TOF/MS确定了46个常见的峰值.
丁醇分离物体表现出最强的抗焦虑作用.
14种化合物,包括regaloside A-D,H,actoside和isoacteoside,被确定与抗焦虑疗效高度相关,并且在体外显示出对神经元细胞的保护作用.

结论:

丁醇分数是BDD治疗焦虑的主要活性分数.
证实了14种特定化合物是主要的焦虑缓解成分,验证了光谱效应分析预测.
这项研究强调了光谱效应分析的准确性和可靠性,用于识别传统中医药中的活性成分.

关键词:

焦虑焦虑是一种焦虑.巴伊赫迪胡安 (Baihe Dihuang) 蒸的方法染色学指纹的指纹多变量统计分析.频谱效应关系的频谱效应关系

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