与迫在眉的突然心脏骤停相关的警告症状:以外部验证为基础的基于人口的病例控制研究
Kyndaron Reinier1, Bernadine Dizon1, Harpriya Chugh1
1Center for Cardiac Arrest Prevention, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Health System, Los Angeles, CA, USA.
The Lancet. Digital health
|August 28, 2023
概括
胸痛和呼吸短促等警告症状与突然心脏骤停 (SCA) 有关. 这些症状,特别是在男性中,可能有助于预测SCA事件,但需要进一步研究.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 数字健康数字健康
背景情况:
- 突然心脏骤停 (SCA) 是一个关键的全球健康问题,死亡率超过90%.
- 停药前预警症状为基于数字技术的干预提供了一个机会,以改善生存率.
- 了解症状与即将发生的SCA之间的关联对于开发预测工具至关重要.
研究的目的:
- 估计特定症状与即将发生的突然心脏骤停之间的关联强度.
- 调查SCA之前的警告症状的潜在性别特异性差异.
- 探索预先逮捕症状对预测SCA事件的有用性.
主要方法:
- 一项病例控制研究利用了来自美国两个社区研究 (PRESTO和SUDS) 的数据.
- 包括18-85岁的个体,目睹了突然心脏骤停和具有类似症状的对照组.
- 使用后勤回归模型来评估发现和复制人群中的症状关联.
主要成果:
- 与对照人群相比,患有SCA的患者更有可能报告呼吸不全,胸痛,腹和类似发作的活动.
- 性别分析显示,男性与SCA相关的胸部疼痛,呼吸不良和隔膜症,而女性只有呼吸不良显著.
- 在复制群体中,研究结果基本一致,症状与性别的关联有所不同.
结论:
- 在SCA之前的警告症状的流行率和模式是性别特异性的.
- 警告症状显示,预测即将发生的SCA具有前途,但可能需要额外的功能来最大限度地提高预测能力.
- 需要进一步的研究来完善使用症状数据和潜在的其他数字生物标志物的SCA预测模型.
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