炎症表型在患有易恶化的喘和持续治疗的患者中的作用
María Florencia Pilia1, María Jesús Cruz2, Donghai Ma3
1Servei de Pneumologia, Hospital Universitari Vall d́Hebron, Departament de Medicina, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain.
Archivos de bronconeumologia
|August 28, 2023
概括
识别易恶化的喘 (EPA) 是至关重要的. 这项研究发现,呼吸道和血液中异性炎症并不能预测控制器治疗喘患者的EPA.
科学领域:
- 肺部病理学 肺部病理学
- 过敏和免疫学 过敏和免疫学
- 临床医学 临床医学
背景情况:
- 在接受现有治疗的患者中,频繁出现喘恶化的危险因素尚未得到充分证实.
- 喘易恶化的患者 (EPA) 被定义为在前一年有两次或更多次喘恶化的患者.
研究的目的:
- 为了比较EPA患者的临床和炎症特征与患有较少恶化的患者.
- 为了确定炎症标志物是否预测控制器治疗喘患者的EPA.
主要方法:
- 在第三级医院进行了一项宏观的观察性研究.
- 包括接受治疗的中度至重度喘患者,评估过敏状况,血液中氨酸友好症和诱导.
- 将患者分类为EPA (每年≥2次恶化) 或非恶化者 (每年≤1次恶化).
主要成果:
- 在具有完整炎症概况的96名患者中,46名 (47%) 是EPA,50名 (53%) 是非恶化剂.
- 在EPA和非恶化剂组之间,呼吸道或血液中异性炎症没有显著差异.
- 在这个队列中,埃索诺菲尔炎症没有被确定为EPA的危险因素.
结论:
- 气道或血液中的2型炎症标志物对于识别EPA是不可靠的.
- 这些标志物不能预测在接受控制剂治疗的患者中喘恶化.
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