牙周病与全身性疾病之间的双向关联:韩国一项全国性基于人口的研究
Salma Nabila1,2, Jaesung Choi3,4, Ji-Eun Kim1,2
1Department of Biomedical Sciences, Seoul National University Graduate School, 103 Daehak-ro, Jongno-gu, Seoul, 110-799, Korea.
Scientific reports
|August 28, 2023
概括
牙周病 (PD) 与患上糖尿病 (DM) 和心血管疾病 (CVD) 的风险更高. 此外,PD和CVD之间存在双向关系.
科学领域:
- 口腔健康 口腔健康
- 系统性疾病 系统性疾病
- 流行病学 流行病学
背景情况:
- 牙周病 (PD) 是一种慢性炎症状况,影响牙和支骨.
- 诸如糖尿病 (DM) 和心血管疾病 (CVD) 等系统性疾病与PD有共同的风险因素和炎症途径.
- 了解PD和全身性疾病之间的相互关联对于全面的患者护理至关重要.
研究的目的:
- 调查牙周病 (PD) 与患上糖尿病 (DM) 的风险之间的关联.
- 检查牙周病 (PD) 与患心血管疾病 (CVD) 的风险之间的关联.
- 评估牙周病 (PD) 和心血管疾病 (CVD) 之间的双向关系.
主要方法:
- 一项前性队列研究,利用来自韩国三个数据库的链接数据,跨越2007-2019年.
- 形成三个不同的研究小组来评估PD,DM和CVD的风险,通过医生诊断,病历和自我报告确认疾病.
- 应用Cox比例危险回归分析以95%的置信区间 (CI) 来计算对多个共变量进行调整后的危险比率 (HR).
主要成果:
- 牙周病 (PD) 与患上糖尿病 (DM) 的风险增加显著相关 (HR [95% CI]:1.22 [1.07-1.39]).
- 患PD也与心血管疾病 (CVD) 的更高风险有关 (HR [95% CI]:1.27 [1.03-1.57]).
- 观察到一种双向关联,心血管疾病增加了PD的风险 (HR [95% CI]: 1.20 [1.09-1.32]),独立于DM状态.
结论:
- 牙周病是糖尿病和心血管疾病的独立风险因素.
- 牙周病和心血管疾病之间存在显著的双向关系.
- 这些发现强调了管理牙周健康对于预防和管理全身性疾病的重要性.
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