通过IRAK-M途径调节炎症可能与nAchRalpha7激活和COVID-19有关
Alessanda S Rieder1, Angela T S Wyse2
1Laboratory of Neuroprotection and Neurometabolic Diseases (Wyse's Lab), Department of Biochemistry, ICBS, Universidade Federal Do Rio Grande Do Sul (UFRGS), Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre RS, 90035-003, Brazil.
Molecular neurobiology
|August 28, 2023
概括
在SARS-CoV-2尖端蛋白与尼古丁受体α7 (nAchRalpha7) 和类似收费受体 (TLRs) 相互作用,影响炎症和IRAK-M通路. 这项研究探讨了COVID-19炎症反应中的IRAK-M调节.
科学领域:
- 神经免疫学 神经免疫学
- 传染性疾病 传染性疾病
- 分子生物学分子生物学
背景情况:
- COVID-19的严重程度与细胞因子风暴和炎症有关.
- 尼古丁胆能系统通过nAchRalpha7在炎症中起着保护作用.
- 在SARS-CoV-2中,尖端蛋白 (Spro) 与nAchRalpha7相互作用,并激活通类受体 (TLRs).
研究的目的:
- 研究SARS-CoV-2 Spro,胆固醇系统和IRAK-M通路之间的对抗性相互作用.
- 了解微质表型在应对SARS-CoV-2感染时的调节.
- 讨论激活胆固醇信号传递期间炎症细胞中的IRAK-M表达.
主要方法:
- 审查有关SARS-CoV-2,胆固醇系统,TLRs和IRAK家族的现有文献.
- 对Spro,nAchRalpha7和TLRs之间的分子相互作用进行分析.
- 讨论IRAK-M在调节微质和炎症细胞反应中的作用.
主要成果:
- SARS-CoV-2 Spro激活了TLRs,从而启动了炎症途径.
- 伊拉克-M 负面调节由其他伊拉克介导的炎症反应.
- 在Spro和胆固醇系统对IRAK-M和微质细胞的影响之间存在敌对关系.
结论:
- SARS-CoV-2 Spro与胆固醇系统之间的相互作用显著影响了IRAK-M调节.
- 了解这些相互作用对于管理COVID-19引起的炎症至关重要.
- 在SARS-CoV-2感染中,IRAK-M调制可能代表治疗点.
相关概念视频
The JAK-STAT Signaling Pathway
9.0K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.0K
T Cell Types and Functions
1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
Inflammatory Response
2.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.1K
NF-κB-dependent Signaling Pathway
7.5K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.5K
Regulation of the Unfolded Protein Response
2.5K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.5K
Inflammation
53.8K
Overview
53.8K


