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Updated: Jul 17, 2025

Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions
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Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions

Published on: August 27, 2014

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一种化化学诱导二元化技术,用于控制,成像和检测蛋白质接近度

Sara Bottone1, Octave Joliot2, Zeyneb Vildan Cakil1

  • 1Sorbonne Université, École Normale Supérieure, Université PSL, CNRS, Laboratoire des Biomolécules, Paris, France.

Nature methods
|August 28, 2023
PubMed
概括

通过素诱导识别 (CATCHFIRE) 进行化学辅助的奇梅拉连接,可以实时监测蛋白质的近距离. 这项技术允许精确控制和跟踪细胞过程,具有高时空分辨率.

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Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
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