不同结直肠癌查策略的表现:中国北京的一个长期被动随访基于人口的查计划
Xi Zhang1, Lei Yang1, Shuo Liu1
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing Office for Cancer Prevention and Control, Peking University Cancer Hospital & Institute, Beijing, 100142, People's Republic of China.
BMC public health
|August 28, 2023
概括
北京结肠直肠癌 (CRC) 查计划有效地使用风险评估问卷和便免疫化学测试 (FIT) 检测早期的CRC. 组合查方法显示高灵敏度,但结肠镜符合性需要改进.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 查计划 查计划
背景情况:
- 结肠直肠癌 (CRC) 是一个严重的健康负担.
- 有效的查策略对于早期检测和改善结果至关重要.
- 中国以人口为基础的CRC查计划需要强大的性能数据来优化.
研究的目的:
- 评估风险评估问卷和便免疫化学测试 (FIT) 在中国CRC查计划中的表现.
- 为制定定制查策略提供证据.
- 评估查方法的检测率和早期诊断能力.
主要方法:
- 分析了北京癌症查前性队列研究 (BCSPCS) 的数据.
- 使用风险评估问卷和FIT作为主要查工具.
- 诊断结肠镜检查的转诊阳性病例,并与北京癌症登记处 (BCR) 联系在一起.
主要成果:
- 总共有147,807名参与者填写了风险评估问卷,115606人填写了FIT.
- 综合风险评估问卷和FIT显示高灵敏度 (95.1%) 和特异性 (70.7%).
- 查计划发现了91例CRC病例,其中63.7%的病例在早期被诊断出来,并且在高风险组 (418.9/100,000) 中发现了更高的发病率.
结论:
- 北京的CRC查计划有效地检测了早期的CRC.
- 风险评估问卷和FIT的联合使用提供了高诊断性能.
- 改善对推的诊断结肠镜检查的遵守仍然是一个关键的挑战.
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