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长期接触聚烯微塑料会引发丸过早衰老

Deyi Wu¹, Meng Zhang¹, Ting Ting Bao²

¹College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.

Particle and fibre toxicology

|August 28, 2023

概括

聚烯微塑料 (PS-MPs) 通过激活Ca2+/ROS/NF-κB信号通路,导致丸过早衰老. 这项研究揭示了微塑料对男性生殖系统的毒性,突出了氧化应激和炎症.

科学领域:

环境毒理学环境毒理学
生殖生物学生殖生物学
细胞衰老细胞衰老

背景情况:

塑料污染,特别是微塑料 (MP),对环境和健康构成重大风险.
在动物和人类组织中积累的MPs需要对其毒理作用进行研究.
国会议员对生殖系统的影响需要进行彻底评估.

研究的目的:

研究聚烯微塑料 (PS-MPs) 对丸过早衰老的影响.
为了阐明背后的分子机制PS-MP诱导的丸衰老.
评估PS-MPs对丸健康的体外和体内影响.

主要方法:

在体外研究中,使用用PS-MPs治疗的TM4细胞来评估衰老标志物和分子通路.
对反应性氧物种 (ROS),线粒体ROS (mtROS) 和线粒体的研究.
在体内研究中,使用暴露于PS-MPs的C57小鼠来评估丸衰老标志物,氧化应激和炎症.

主要成果:

通过Ca2+/ROS/NF-κB信号轴,PS-MPs在丸塞尔托利细胞 (TM4细胞) 中诱导过早衰老.
PS-MPs通过导致Ca2+过载和抑制线粒细胞衰变,触发了线粒体ROS积累.
在体内,PS-MPs暴露导致小鼠的丸过早衰老,氧化应激和炎症.

结论:

由PS-MP诱导的丸过早衰老是由Ca2+/ROS/NF-κB信号通路介导的.
微塑料暴露会通过氧化应激和炎症显著影响男性生殖健康.
这项研究为了解生殖系统中的微塑料毒理学提供了基础.

关键词:

这就是NF-κBB.聚乙烯微塑料的微塑料.丸过早衰老的原因这就是ROSOS ROS.在TM4细胞中,

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