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免疫球蛋白A缺乏症的临床表现:系统性审查和元分析
Ahmad Vosughimotlagh1, Seyed Erfan Rasouli2, Hosein Rafiemanesh3
1Department of Pediatrics, North Khorasan University of Medical Sciences, Bojnurd, Iran.
概括
免疫球蛋白A缺乏症 (IgAD) 是一种常见的疾病,具有不同的临床结果. 感染是最常见的,其次是过敏性疾病和自身免疫,需要定期监测患者.
科学领域:
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
- 遗传学 是一个遗传学.
背景情况:
- 免疫球蛋白A缺乏症 (IgAD) 是一种普遍存在的疾病,遗传基础不明.
- 它的特征是IgA水平低或不存在,其他免疫球蛋白,亚类和特定抗体的水平正常.
- IgAD 患者表现出广泛的临床表现,包括感染,自身免疫性疾病,恶性瘤和过敏性疾病.
研究的目的:
- 评估免疫球蛋白A缺乏症 (IgAD) 患者中各种临床表现的发生率.
- 为了分类与IgAD相关的常见临床结果.
主要方法:
- 在PubMed,Web of Science和Scopus数据库中进行了系统的文献搜索,截至2022年1月.
- 用随机效应模型计算了临床表现的聚合流行率估计和95%置信区间.
主要成果:
- 感染是最常见的表现 (64.8%),其次是过敏性疾病 (26.16%) 和自身免疫性 (22.0%).
- 在自身免疫性疾病中,乳病 (6.57%),炎症性肠病 (4.01%) 和类风湿性关节炎 (3.80%) 在选择性IgA缺乏症中最常见.
- 呼吸道感染 (50.74%),真菌感染 (18.48%) 和胃肠道感染 (15.79%) 是最常见的感染. 喘 (19.06%),过敏性鼻炎 (15.46%) 和过敏性结膜炎 (11.68%) 是最常见的过敏性疾病.
结论:
- IgAD 患者表现出广泛的临床表现,感染,过敏和自身免疫性疾病是最常见的.
- 同时缺少IgA和IgG亚型可能会增加对感染的易感性.
- 建议对IgAD患者进行定期监测,因为随着时间的推移可能出现新的临床并发症.
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