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Updated: Jul 17, 2025

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
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Published on: October 23, 2019

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通过结合机器学习,基于结构的药模拟和生物评估,发现了新的JAK1抑制剂

Zixiao Wang1, Lili Sun2, Yu Xu3

  • 1Department of Pharmacy, Honghui Hospital, Xi' an Jiaotong University, Xi' an, 710054, China. zixiaowang1112@foxmail.com.

Journal of translational medicine
|August 28, 2023
PubMed
概括

这项研究开发了一种机器学习和药模型,以识别用于治疗炎症性疾病和癌症的Janus激酶1 (JAK1) 抑制剂. 四种化合物显示出显著的活性,其中Z-10是最强大的JAK1抑制剂.

关键词:
亚努斯酶 1 亚努斯酶 1机器学习是机器学习.分子动力学模拟的模拟.药科类动物 (Pharmacophore) 是一种药科类动物.虚拟选是一个虚拟的选.

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