在加拿大获得癌症临床试验的地理差异
1Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, AB, Canada.
American journal of clinical oncology
|August 29, 2023
概括
在加拿大癌症临床试验中存在地理和癌症类型的差异. COVID-19大流行也对临床试验的可访问性产生了负面影响,突出了临床试验参与中的不平等.
科学领域:
- 在瘤学瘤学.
- 临床试验 研究 研究 临床试验 临床试验
- 医疗保健服务研究 医疗服务研究
背景情况:
- 公平获得癌症临床试验对于推进癌症护理和确保所有患者可以从新型治疗中受益至关重要.
- 地理和人口因素可能会影响患者参与临床试验,这可能导致获得机会的差异.
研究的目的:
- 评估在加拿大获得癌症临床试验的地理差异.
- 分析癌症临床试验注册和资金来源的趋势.
- 为了比较加拿大和美国之间的癌症临床试验可用性.
主要方法:
- 来自clinicaltrials.gov的癌症临床试验数据,用于2005年至2023年期间在加拿大进行的试验.
- 根据位置 (国家,省,城市中心),癌症类型,资金来源和时间段进行频率分析.
- 计算了加拿大和美国每1万人的癌症临床试验.
主要成果:
- 观察到显著的地理差异,癌症临床试验每10,000人从新不伦瑞克省的6.79到各领地的0不等.
- 与预计病例相比,淋巴瘤试验 (32.85/1000例) 是最多的,而膀癌试验 (7.06/1000例) 是最少的.
- 行业资金占试验的69%,最高的试验活动发生在2014-2016年期间,与2020-2022年相比显著下降.
结论:
- 加拿大对癌症临床试验的准入分布不公平,受地理位置和原发性瘤部位的影响.
- 随着COVID-19的流行,癌症临床试验的获取现有的差异进一步加剧.
- 解决这些差异对于改善全国癌症护理结果至关重要.
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