甲福明降低了瘤生长在一个小鼠侧翼瘤模型
Sudhir Manickavel1, Yolanda Hartman1, Andrew Burns1
1Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
概括
甲胺和阿司匹林显著降低了小鼠前庭神经瘤 (VS) 的生长. 在停止治疗后,瘤的生长恢复,这表明这些药物在VS管理中具有潜在的治疗作用.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 神经外科 神经外科
背景情况:
- 前庭神经瘤 (Vestibular schwannoma,简称VS) 是一种影响前庭神经神经神经膜的瘤.
- 以前的研究表明,甲福明和阿司匹林可能会抑制VS的生长.
- 这项研究调查了甲福明和阿司匹林在减少VS瘤体积方面的疗效.
研究的目的:
- 评估甲胺和阿司匹林在体外模型中对前庭瘤生长的影响.
- 为了比较低剂量和高剂量甲胺和阿司匹林与安慰剂的影响.
- 为了评估治疗停止后的瘤生长动态.
主要方法:
- 鼠 schwannoma 细胞植入了 50 个无人性裸体小鼠.
- 在每天注射低剂量或高剂量的甲福林,阿司匹林或盐水之前,瘤被允许生长到5毫米.
- 瘤大小和生长速度被监测了14天,在停止治疗后继续观察.
主要成果:
- 与安慰剂相比,低剂量的甲福明和阿司匹林在第7天显著降低了瘤体积 (分别为p=0.04和p=0.02).
- 平均瘤生长率在低剂量甲素 (73.7 mm3/day) 和阿司匹林 (68.7 mm3/day) 与盐水 (126.6 mm3/day) 相比显著降低.
- 在停止治疗甲胺 (p=0.048) 和阿司匹林 (p=0.006) 后,瘤生长显著增加.
结论:
- 梅特福林有效地减少前庭神经瘤的生长,与阿司匹林相当.
- 甲福明和阿司匹林都显示,在停止治疗后,瘤生长有显著的反弹.
- 这些发现表明,甲胺和阿司匹林在控制前庭神经瘤生长方面可能发挥作用.
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