余动脉样硬化心血管疾病风险:关注非高密度脂蛋白胆固醇
1Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, China.
Journal of cardiovascular pharmacology and therapeutics
|August 29, 2023
概括
与LDL-C相比,非高密度脂蛋白胆固醇 (非HDL-C) 是心血管疾病 (CVD) 风险的优越预测因素. 提高非高密度血清-C的认识和例行测试对于有效预防心血管疾病至关重要.
科学领域:
- 心脏病学 心脏病学
- 脂质学 脂质学是指脂质学.
- 预防医学 预防医学
背景情况:
- 由于动脉样硬化的心血管疾病 (CVD) 是全球主要的死亡原因.
- 低密度脂蛋白胆固醇 (LDL-C) 是心血管疾病的主要预测因素,也是降脂疗法的目标,但残留风险仍然存在.
- 剩余的心血管疾病风险与残留胆固醇,高甘油三和低高密度脂蛋白胆固醇 (HDL-C) 有关.
研究的目的:
- 突出非高密度脂蛋白胆固醇 (非高密度脂蛋白胆固醇-C) 作为心血管疾病风险的优越预测因素,而不是LDL-C.
- 强调非HDL-C在评估残留心血管疾病风险中的作用.
- 倡导提高临床意识和对非高血压-C进行常规测试,以评估和预防心脏病风险.
主要方法:
- 对当前文献和临床指导方针的审查,涉及脂质概况和心血管疾病风险评估.
- 非HDL-C和LDL-C作为动脉样硬化心血管疾病 (ASCVD) 的预测因素的比较.
- 讨论非HDL-C降低策略和推的目标水平.
主要成果:
- 非HDL-C,代表所有异性质脂蛋白中的胆固醇,是比LDL-C更好的心血管疾病风险预测指标.
- 国际指导方针建议非HDL-C评估,特别是对于高危人群 (例如,高甘油三,糖尿病,肥胖).
- 非常高风险患者推的非HDL-C目标为<130 mg/dL (3.4 mmol/L).
结论:
- 非HDL-C提供了更全面的评估,以腺原脂蛋白负担和心血管疾病风险.
- 尽管有推,但非HDL-C测试在临床实践中并不经常进行.
- 提高非HDL-C测试的临床意识和实施对于改善心血管疾病风险分层和预防至关重要.
相关概念视频
Atherosclerosis III: Management
12
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
12
Atherosclerosis I: Introduction
10
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
10
Coronary Artery Disease IV: Preventive Measures
23
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
23
Coronary Artery Disease I: Introduction
20
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
20
Coronary Artery Disease II: Pathophysiology
12
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
12
Blood Studies for Cardiovascular System III: Serum Lipid Profile
190
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
190


