在儿科患者的口服食物挑战和药物诱导测试中出现过敏反应的发展
相关实验视频
Updated: Jul 17, 2025

07:22
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
8.3K
Irem Turgay Yagmur1, Ilknur Kulhas Celik2, Ozge Yilmaz Topal3
1From the Department of Pediatric Allergy and Immunology, Ankara City Hospital, Ankara, Turkey.
Allergy and asthma proceedings
|August 29, 2023
概括
在儿童的口服食物挑战 (OFC) 和药物诱导测试 (DPT) 期间,可发生过敏反应. 这些诊断程序需要经验丰富的过敏学家在设备齐全的环境中仔细监测.
科学领域:
- 儿科过敏和免疫学
- 临床诊断 临床诊断 临床诊断
- 药物不良反应 药物不良反应
背景情况:
- 口服食物挑战 (OFC) 和药物诱导测试 (DPT) 是诊断食物过敏和药物过敏的黄金标准.
- 在这些关键的诊断过程中,可能会出现严重的过敏反应,包括过敏反应.
- 了解OFC和DPT期间过敏反应的发生率和特征对于患者的安全至关重要.
研究的目的:
- 在接受OFC和DPT的儿科患者中确定过敏反应的频率.
- 在这些诊断试验中,描述过敏反应的临床特征和触发因素.
- 在患有过敏反应的儿科患者中识别相关的过敏状况.
主要方法:
- 2014年1月至2021年1月,在儿童过敏诊所进行的OFC和DPT的回顾性审查.
- 对2588名儿科患者进行的3631个OFC和/或DPT的分析.
- 评估过敏反应的特征,包括触发因素,症状和严重程度.
主要成果:
- 在OFC和DPT的1.2% (42/3631) 发生过敏反应.
- 常见的OFC触发物包括酸奶,母蛋和牛奶;布洛芬是经常发生的DPT触发物.
- 患者表现出皮肤和呼吸系统症状;接受OFC治疗的患者经常患有亚托皮炎和喘.
结论:
- 过敏反应在儿科患者的OFC和DPT期间是一个潜在的风险.
- 这些诊断测试需要由熟练的过敏学家在为紧急情况配备的设施中进行.
- 随时可用的紧急药物,如上腺素,对于在这些程序期间控制过敏反应至关重要.
相关概念视频
Allergic Reactions
27.8K
Overview
27.8K
Allergic Drug Reactions
875
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
875
Hypersensitivities
735
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
735
Cross-reactivity
31.2K
Overview
31.2K
Desensitization and Tachyphylaxis
1.8K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.8K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
342
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
342

