相关实验视频

Updated: Jul 17, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

自免疫性疾病与常见变性免疫缺陷患者血清基础免疫球蛋白E水平之间的关系

Mehmet Kılınc¹, Fatih Colkesen¹, Recep Evcen¹

¹From the Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey, and.

Allergy and asthma proceedings

|August 29, 2023

概括

低免疫球蛋白E (IgE) 水平与常见变性免疫缺陷 (CVID) 患者的自身免疫性疾病有关. 监测IgE可能有助于早期诊断和治疗CVID的自身免疫性.

科学领域:

免疫学免疫学免疫学
临床医学临床医学

背景情况:

自免疫性疾病在常见的可变免疫缺陷 (CVID) 中很常见.
低免疫球蛋白E (IgE) 与CVID自身免疫力之间的联系尚不清楚.

研究的目的:

研究成年CVID患者低血清IgE水平和自身免疫疾病之间的关联.

主要方法:

62名成年CVID患者的回顾性队列研究 (2012年4月至2021年12月).
在有或没有自身免疫性疾病的CVID患者之间,血清IgE水平的比较.
统计分析以确定自身免疫的风险因素.

主要成果:

37.1%的CVID患者患有自身免疫性疾病 (CVID-O).
与没有CVID-O的患者相比,患有CVID-O的患者血清IgE水平中位数显著降低 (2 IU/mL) (p < 0.001).
低IgE是CVID自身免疫性的一个独立风险因素 (OR 3.081,p = 0.017).

结论:

低血清IgE水平与CVID中自身免疫性疾病的发展有关.
监测IgE可能有助于早期诊断和治疗CVID患者的自身免疫性疾病.

更多相关视频

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

相关概念视频

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...