感觉运动关联性可塑性的小脑调节在宫性 dystonia 中受损
Kai Grimm1, Lisa Prilop1, Gerhard Schön2
1Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
概括
脑小叶刺激对宫 dystonia (CD) 患者的感觉运动可塑性产生不同的影响,与健康个体相比. 在对照组中具有抑制作用的阴极刺激对CD可塑性没有影响,这表明在 dystonia 中大脑 - 丘脑 - 皮质网络功能发生了改变.
科学领域:
- 神经科学是一个神经科学.
- 运动障碍 运动障碍
- 大脑小叶的功能
背景情况:
- 宫性 dystonia (CD) 越来越多地被视为影响多个大脑区域的网络障碍,包括小脑.
- 小脑在 dystonia 病理生理学中的特定作用仍然不太清楚.
研究的目的:
- 为了研究小脑对宫 dystonia 患者的感觉运动关联性可塑性的影响.
- 为了比较CD患者和健康对照者之间的小脑调节效应.
主要方法:
- 在16名CD患者和13名对照人群中,进行大脑小脑跨直流刺激 (ctDCS) (阳极,阴极,模拟) 随后进行配对关联刺激 (PAS).
- 在双盲交叉设计中,干预前后评估运动皮层刺激性和运动症状严重程度.
主要成果:
- 在这两组中,PAS增加了运动皮层刺激能力.
- 在健康人群中,阳极和阴极ctDCS减弱了PAS效应,而阴极显示出更强的影响.
- 在CD患者中,阳极ctDCS抑制了PAS效应,而正极ctDCS没有显著的影响.
结论:
- 在CD患者中,大脑小脑阴极刺激没有影响感觉运动关联性可塑性,与健康人群不同.
- 这些发现支持大脑 - 丘脑 - 皮质网络参与宫性 dystonia 的病理生理学.
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