第一个双胞胎或单胞胎怀孕后,随后的单胞胎怀孕的出生体重
Prativa Basnet1, Rolv Skjaerven1,2, Quaker E Harmon3
1Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.
Acta obstetricia et gynecologica Scandinavica
|August 29, 2023
概括
随后的单子出生体重是相似的,无论第一个怀孕是双胞胎还是单子. 这表明,对出生体重的平价效应不能通过双胞胎怀孕中子宫扩张的更大程度来解释.
科学领域:
- 生殖健康 生殖健康
- 围产期流行病学 围产期流行病学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 出生体重是婴儿健康和长期福祉的关键指标.
- 以前的研究表明,平价 (以前的出生人数) 影响着出生体重,而第二名婴儿通常更重.
- 现有的研究往往忽略了更高阶的怀孕,主要关注单身.
研究的目的:
- 为了调查第一个双胞胎怀孕是否会影响后续单独子女的出生体重,与第一个单独怀孕的女性相比.
- 分析之前双胞胎怀孕对随后单子出生体重的独立影响.
主要方法:
- 一项基于登记的前性队列研究,利用挪威医疗出生登记 (1967-2020).
- 包括778,975名妇女,根据第一个怀孕类型 (双胞胎与单胞胎) 进行后续单子怀孕的出生体重比较.
- 使用调整后线性回归的统计分析,对母亲的年龄,年龄,教育和出生国进行控制.
主要成果:
- 初生双胞胎的联合出生体重 (>1000g) 比初生单胞胎高得多.
- 随后的单子分娩体重显示,第一次双胞胎怀孕与第一次单子怀孕的妇女之间的最小调整差异为21g (95%CI 5-37g).
- 第一次双胞胎怀孕的总出生体重增加并没有转化为随后单子出生体重的实质性差异.
结论:
- 随后的单子出生体重是可比的,无论第一个怀孕是否涉及双胞胎或单子.
- 这些发现挑战了在双胞胎怀孕中子宫扩张增加的假设,解释了出生体重的一般平衡效应.
- 需要进一步的研究来阐明生理机制背后的平价效应对出生体重.
相关概念视频
Regression Toward the Mean
6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Pathophysiology of Diabetes
986
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
986
Probability Laws
41.0K
Overview
41.0K
z Scores and Area Under the Curve
10.9K
z scores are the standardized values obtained after converting a normal distribution into a standard normal distribution. A z score is measured in units of the standard deviation. The z score tells you how many standard deviations the value x is above (to the right of) or below (to the left of) the mean, μ. Values of x that are larger than the mean have positive z scores, and values of x that are smaller than the mean have negative z scores. If x equals the mean, then x has a z score of...
10.9K
Ovarian Cycle
1.3K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.3K
Teratogenicity
2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K


