参与心肺呼吸控制的脑髓血清中心因胎儿生长限制而受到干扰
Elham Ahmadzadeh1,2, Ingrid Dudink1,2, David W Walker3
1The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
The Journal of physiology
|August 29, 2023
概括
早期胎儿生长限制 (FGR) 在绵羊中引起脑干神经病理,影响心肺呼吸控制中心. 这种情况涉及细胞死亡,炎症和改变的血清水平,影响新生儿的健康.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 围产儿医学 围产儿医学
背景情况:
- 胎儿生长限制 (FGR) 与出生后心血管和呼吸系统不良结果有关.
- 记录了FGR的神经变化,但脑干心肺呼吸中心仍未得到充分研究.
- 大脑干中产生血清素的神经元对于心肺呼吸调节至关重要,可能会受到FGR的影响.
研究的目的:
- 研究早期FGR对脑干心脏呼吸控制中心对胎儿绵羊的影响.
- 评估FGR胎儿大脑干中的组织病理变化,细胞死亡,增殖和神经炎症.
主要方法:
- 早期发病的FGR在妊娠110天和127天的胎羊中被诱导.
- 进行了体和脑髓的组织病理学分析,将FGR胎儿与对照进行了比较.
- 评估细胞死亡,增殖,灰色/白质完整性,氧化应激,神经炎症和血清素/受体水平.
主要成果:
- FGR胎儿表现出慢性低血和不对称的生长限制.
- FGR胎儿的大脑干显示神经病理:细胞死亡增加,增殖减少,灰白质缺乏,氧化应激和神经炎症.
- 特定的核 (骨髓拉菲,低分泌,模两可,单一通道) 主要受到影响.
- 在FGR中观察到大脑干中血清激素和5-HT1A受体水平的不平衡,尽管胎盘血清激素增加了.
结论:
- 早期发病的FGR在胎儿绵羊中诱导了显著的脑干神经病理.
- 这些变化扰乱了神经元发育和心肺呼吸控制中心的功能.
- 胎盘缺陷导致适应性和潜在有害的脑干变化,影响长期的心肺呼吸系统健康.
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