视神经头 perfusion 眼睛的变化与多发性糖尿病视网膜病变治疗与静脉内拉尼比祖马布或光凝:一个随机对照试验
Ahmed Magdy Raffat Helmy1, Mohammad Ahmad Rashad1, Hesham Mohamed Gharieb1
1Ophthalmology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Medical hypothesis, discovery & innovation ophthalmology journal
|August 29, 2023
概括
在患有增殖性糖尿病视网膜病变 (PDR) 的患者中,静脉内射拉尼比祖马布注射比泛视网膜光凝 (PRP) 更多地改善了辐射周围毛细血管 (RPC) 密度和视觉敏度. 拉尼比祖马布增加了RPC密度,而PRP在3个月内降低了它.
科学领域:
- 眼科医生 眼科 眼科
- 糖尿病学 糖尿病学
- 医疗成像医学成像
背景情况:
- 扩散性糖尿病视网膜病变 (PDR) 是不可逆转失明的主要原因.
- 高风险的PDR未经治疗可能导致50%的患者在5年内失明.
- 辐射周毛细血管 (RPC) 密度是PDR中视网膜健康的关键指标.
研究的目的:
- 为了比较泛视网膜光凝 (PRP) 与静脉内拉尼比祖马布注射的疗效.
- 为了评估这些治疗对RPC密度的影响,使用光学连贯性断层扫描血管学 (OCTA).
- 在3个月的随访期内评估视觉敏度和视网膜厚度的变化.
主要方法:
- 一个开放标签,前性,随机临床试验,涉及50名未经治疗的PDR患者.
- 患者被随机分配,接受PRP (两次) 或静脉内拉尼比祖马布注射 (三次0.5毫克剂量).
- 在治疗前和治疗后每月进行一次眼科检查,OCTA和视觉现场测试,持续3个月.
主要成果:
- 在PRP组中,RPC密度显著下降,但在拉尼比祖马布组中增加.
- 与PRP组相比,拉尼比祖马布组的视觉敏性显示出更大的改善.
- 在两个治疗组之间,中心骨厚度的中位变化显著不同.
结论:
- 与PRP相比,内拉尼比祖马布在改善PRC密度和视力敏度方面表现出优异的结果.
- 拉尼比祖马布治疗导致RPC密度增加,而PRP导致减少.
- 建议进行进一步的多中心试验以验证这些发现.
关键词:
糖尿病视网膜病变 - 糖尿病视网膜病变内注射 内注射 内注射激光切除术是一种激光切除术.激光疗法是一种激光疗法.卢森蒂斯是一个明亮的.视神经 视神经 视神经光学连贯性断层扫描技术摄影凝固是指光凝固的过程.更多相关视频
相关概念视频
Open Angle Glaucoma: Treatment
477
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
477
Angle Closure Glaucoma: Treatment
560
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
560
Glaucoma: Overview
619
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
619


