ABCG2 基因多态可能影响受阿皮克萨班和里瓦罗克萨班治疗的患者的出血风险
Hamin Kim1, Tae-Jin Song2, Jeong Yee1
1College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea.
Drug design, development and therapy
|August 29, 2023
概括
在ABCG2和ABCB1中的遗传变异,以及血流和质子抑制剂使用史,与服用阿皮克萨班或里瓦罗克萨班的患者的出血风险有关.
科学领域:
- 药物基因组学 药物基因组学
- 心脏病学 心脏病学
- 在瘤学瘤学.
背景情况:
- 直接口服抗凝剂 (DOAC) 对于预防心房动中风至关重要.
- 流血并发症仍然是DOAC治疗的一个重要问题.
- ABCG2 载体影响了阿皮克萨班和里瓦罗克萨班的药理动力学.
研究的目的:
- 为了研究ABCG2基因变异与治疗阿皮克萨班或里瓦罗克萨班的患者的出血并发症之间的联系.
- 确定导致出血风险的遗传和临床因素.
主要方法:
- 一项涉及293名用阿皮克萨班或里瓦罗克萨班治疗的患者的病例控制研究.
- 对ABCG2和其他相关基因 (ABCB1,CYP3A4,CYP3A5) 中16个单核酸多态的分析.
- 多变量分析以确定出血事件的独立预测因素.
主要成果:
- ABCG2 rs3114018和ABCB1 rs1045642显著与增加出血风险相关.
- 出血史和同时使用质子抑制剂 (PPI) 也被确定为危险因素.
- 修改后的HAS-BLED得分显示出出血并发症的显著预测价值.
结论:
- 除了临床因素,ABCG2 rs3114018和ABCB1 rs1045642与治疗阿皮克萨班/里瓦罗克萨班的患者的出血风险有关.
- 这些发现支持开发个性化治疗策略.
- 整合遗传信息可以优化DOAC治疗,减少出血事件.
更多相关视频
23:33The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
83.7K
07:26High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
Published on: July 18, 2017
11.9K
相关概念视频
01:18Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.2K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.2K
01:12The ABO Blood Group
1.8K
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
1.8K
01:24Disorders of Hemostasis
989
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
989
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
560
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
560
02:45Blood Transfusion and Agglutination
10.9K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.9K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
749
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
749