光学连贯性断层扫描血管学在中级紫外炎相关的囊性黄斑胀中
Leila Alizadeh Ghavidel1, Farideh Mousavi1, Hesam Sadat Hashemi1
1Department of Ophthalmology, Tabriz University of Medical Sciences, Tabriz, Iran.
Medical hypothesis, discovery & innovation ophthalmology journal
|August 29, 2023
概括
中级脑膜炎 (IU) 和不响应的囊状黄斑 (CME) 患者表现出表面毛细血管血管密度降低. 这些发现表明微囊变化和视网膜缺血可能导致UI患者的不响应性CME.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜成像 视网膜成像
- 血管生物学 血管生物学
背景情况:
- 囊性黄斑 (CME) 是脑膜炎视力丧失的主要原因,特别是中间脑膜炎 (IU).
- 了解斑点微血管变化对于在IU患者中管理不响应的CME至关重要.
研究的目的:
- 为了比较不响应CME的IU患者和没有斑点的患者之间的斑点微血管特征.
- 为了确定中级紫外线炎中不响应的CME的潜在成像生物标志物.
主要方法:
- 一个病例控制研究涉及55个眼睛的IU患者.
- 谱域光学连贯性断层扫描血管学 (OCT-A) 用于评估血管密度,状血管区域 (FAZ) 和形态.
- 患者被分为两组:30只眼睛与IU相关的不响应的CME (病例) 和25只眼睛与IU没有黄斑 (对照).
主要成果:
- 表面毛细管 (SCP) 血管密度在病例组与对照组相比显著较低,特别是在副毛细管区域.
- 在体表面血管密度,深毛细血管 (DCP) 血管密度,FAZ指标或FAZ周围的体血管密度方面没有发现显著差异.
- 血管形态变化在两组之间是可比的.
结论:
- 与IU相关的不响应的CME眼睛的SCP血管密度比没有黄斑的眼睛减少.
- 与DCP相比,在CME组中观察到SCP中的囊空间增加.
- 微囊性变化和潜在的视网膜缺血可能是IU中不响应的CME的基础;建议进一步研究.
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